The fine anatomical and histological details will be covered in other courses. Sjogren syndrome in primary salivary gland lymphoma. Salivary glands may be involved in a wide variety of diseases, which may be broadly. Developmental anomalies aberrant salivary glands an aberrant or ectopic is salivary gland tissue that develops at a site where it is not normally found. They all secrete saliva into your mouth, the salivary gland through tubes that drain saliva referred to as salivary glands, close to your higher teeth, submandibular beneath your tongue, and therefore the articulator through several ducts within. How long a salivary gland problem lasts depends on the specific disorder. Sialolithiasis is the most common disease affecting adult salivary glands, accounting for more than 50% of all salivary gland conditions. Salivary gland disease is managed by a number of specialities. Salivary gland disorders may be caused by nonneoplastic conditions or neoplasms. The most important secretion glands are the salivary gland, submandibular, and articulator glands. Salivary glands are essential structures in the oral cavity.
We would like to draw attention to salivary glands in the epidemic process of asymptomatic. Juvenile recurrent parotitis jrp is the second most common salivary gland disease in children. Clinically, the lesion appears in the palate as a deep, sharply defined, up to 3 cm craterlike ulcer that develops rapidly over a few days and fails to heal for an extended period of time. Saliva has great potential as a diagnostic fluid and offers advantage over serum and other biological fluids by an economic and noninvasive collection method for monitoring of systemic health and disease progression. Nonneoplastic disorders of the salivary glands are divided into the following groups.
Salivary gland dysfunction, protein glycooxidation and. It can be used to monitor the presence and levels of hormones, drugs, antibodies, microorganisms and ions. Factors that contribute to dry mouth include systemic disease and medical therapies such as medication or radiation treatment. Get a printable copy pdf file of the complete article 2. Pdf salivary gland diseases in childhood researchgate. A variety of causative factors have been proposed, including congenital ductal malformations, hereditarygenetic factors, viral or bacterial infection, allergy, and local manifestation of an autoimmune disease. Treatment for salivary gland tumors often involves surgery. Salivary gland neoplasms make up 1% of all head and neck tumors 90. Gastroenterology, oral and maxillofacial surgery salivary gland diseases sgd are multiple and varied in cause. The salivary glands produce saliva to moisten the mouth, to help protect teeth from decay and to digest food. Pdf recent advances in the management of salivary gland disease.
Salivary glands may be affected by a number of diseases. Arrow marks pus coming out of the opening of the submandibular gland. Mar 12, 2012 f infection viral bacterial mycoticg autoimmune disorders sjogrens syndrome mikuliczs disease uveoparotid fever recurrent non specific parotitis 8. Salivary gland anatomy n parotid gland n submandibular gland n sublingual gland n minor glands it is not our intent to cover anatomy during this course. Giant salivary calculi of the submandibular gland journal. Introduction to salivary glands university of michigan. Mumps, human immunodeficiency virus associated salivary gland disorder. Common presentations, such as a painful or swollen gland, can be caused by numerous disorders of strikingly variable severity and consequences, including inflammatory, infectious, and neoplastic conditions, for which treatment can differ significantly, and referral for specialty care is sometimes necessary. Approximately 25 percent of parotid tumors are cancerous malignant. Salivary glands are unique because of the manifold subtypes of benign and malignant diseases found there. The plethora of components in this fluid can act as biomarkers for diagnosis of various.
As a result, gps often only experience limited exposure to salivary gland disorders. Oral diagnostic approaches to the patients with salivary gland disorders. Review of the major and minor salivary glands, part 1. Primary salivary gland lymphoma sgl is an uncommon neoplasm that accounts for less than 10% of salivary gland tumors and less than 5% of all extranodal nonhodgkin lymphomas 14. A 46yearold man with salivary duct carcinoma of the right parotid gland presented for evaluation of a 3week history of multiple new pruritic skin lesions on the right chest and endorsed erythematous skin changes within the field of radiation. Physiology, pathology and regeneration of salivary glands mdpi. Salivary secretory disorders, inducing drugs, and clinical. It occurs when white blood cells target healthy cells in moistureproducing glands, such as the salivary. Apr 02, 2020 causes of salivary gland problems include infections, obstruction, or cancer. According to a latest report on coronavirus disease 2019 covid19, authors had drawn attention to dental risk, in which asymptomatic patients had been mentioned many times meng et al. The three major salivary glands are the parotid gland, submandibular gland also called the submaxillary gland and sublingual glands. Blockage of the submandibular gland by a stone with subsequent infection. Treatments for salivary gland tumors may also include radiation therapy and chemotherapy.
The presentation can be the presentation can be acute, recurrent, or chronic. Early detection of disease plays a crucial role for treatment planning and prognosis. Advances in diagnosis and management of salivary gland diseases. This chapter will provide an overview of the functions of saliva, the anatomy and.
The less common salivary gland diseases were sialadenitis and sialadenosis. Pdf on aug 1, 2019, ali ali alzamzami published classification of salivary gland diseases among yemenis. Salivary gland is one of the main soft tissue structures in the maxillofacial area. Pdf salivary gland diseases in children are rare, apart from viralinduced diseases. Igg4related disease igg4rd is a rare fibroinflammatory condition that can affect almost any organ, characterized by swollen lesions and often by eosinophilia and elevated serum igg4 concentrations. Managing xerostomia and salivary gland hypofunction. Mumps is the most common salivary gland infection caused by paramyxovirus fields et al. Following radiotherapy of the head and neck region, salivary gland dysfunction is a predictable sideeffect.
Salivary secretion in health and disease article pdf. Jan 22, 2014 an estimated 750 deaths related to salivary gland tumors occur annually. This is removal of a small piece of tissue to diagnose a cyst, tumor, or sjgrens syndrome. Salivary gland disease necrotizing sialometaplasia ns is a benign, selflimited, reactive inflammatory process involving minor mucoserous salivary glands. Post irradiation sialadenitis, chronic sclerosing sialadenitis, cheilitis. Salivary gland sporozoite load is significantly associated with the likelihood of malaria infection odds ratio 7.
A variety of diseases, such as cancer, autoimmune diseases, infections and physical traumas, can alter the functionality of. A guide to salivary gland disorders mcewen aorn journal. For example, if you have a mass in your salivary gland, your doctor may recommend surgery to remove the. Salivary gland disorders karan jolly, paul davies, neil. Saliva drains into the mouth through small tubes called ducts. Neoplasms manifest themselves as benign or malignant tumors of the salivary glands. Diagnosis and management fills a major gap in the literature by presenting modern and uptodate knowledge on all aspects of this important field. The anatomy and physiology of salivary glands benefits of saliva is that it is easily available for noninvasive collection and analysis. Written by worldrenowned experts, salivary gland disorders and diseases. This study is the first to evaluate protein glycooxidation products, lipid oxidative damage and nitrosative stress in nonstimulated nws and stimulated whole saliva sws of children with chronic kidney disease ckd divided into two subgroups. Problems can also be due to other disorders, such as mumps or sjogrens syndrome. A literature search was conducted with the assistance of a research librarian in the medlinepubmed database. Jun 01, 2014 salivary gland disorders include inflammatory, bacterial, viral, and neoplastic etiologies. Twelve per adult population are reported to suffer from the condition each year, with males affected more than females 1.
Salivary gland disease an overview sciencedirect topics. Imaging is useful in identifying the masses of salivary glands and also in differentiating them from the massespathologies of adjacent cervical spaces. Sjogrens syndrome is another common salivary gland disorder. Clinically, mumps sialadenitis begins with a prodromal period followed by acute bilateral salivary gland swelling typically affecting the parotid. Nonneoplastic salivary gland diseases biomedical and. In general, viral infections of the salivary gland may result in reduced saliva production andor swelling. Salivary secretion in health and disease pedersen 2018. The tumors can arise in about 80% in parotid gland, 15% in submandibular gland and 5% in the sublingual and minor salivary gland.
There is a long association between viral infections and diseases of the salivary gland. Salivary gland disease in human immunodeficiency virus. There are three pairs of major salivary glands and several hundred minor salivary. Oct 26, 2018 salivary gland tumors most commonly occur in the parotid gland, accounting for nearly 85 percent of all salivary gland tumors. Occurrence of this lesion in major salivary glands, primarily the parotid gland, is uncommon, representing 8. Malignant lesions typically present after age 60, while benign lesions usually present after age 40. Igg4related disease igg4rd is a rare fibroinflammatory condition that can affect almost any organ 1, 2, including the salivary glands, orbital and periorbital tissues, pancreas, retroperitoneum, and lymph nodes. The chart showing pdf series, word series, html series, scan qr codes. Pdf classification of salivary gland diseases among yemenis. Classification of salivary gland diseases among yemenis. Sep 25, 2015 saliva is formed primarily approximately 90% from the secretions of the three paired major salivary glands, the submandibular around 65%, parotid around 20% and sublingual around 57%.
Mouth dryness or thick saliva american cancer society also in spanish. Nonneoplastic conditions generally are related to inflammatory processes or are secondary to existing disease processes. Salivary gland dysfunction refers to either xerostomia the symptom of dry mouth or salivary gland hypofunction reduced production of saliva. Salivary gland tumors symptoms and causes mayo clinic.
Reduced salivary flow rates have also been attributed to hiv infection, side effect of haart, or in correlation to considerable salivary gland disease 19, 20. Besides congenital diseases of the salivary glands in children, the main etiologies of viral. Igg4rd is characterized by swollen lesions across organs and often by elevated serum igg4 concentrations. Jun 18, 2018 treatment for salivary gland disorders depends on the disease type and how advanced it is. The less common salivary gland diseases were sialadenitis and sialadenosis, accounting,12. Salivary gland tumours tumours of salivary glands represent a complex and histopathologically diverse group of tumour diagnosis and management is complicated by the fact that they are in frequent making up only 1% of head and neck tumour proper management require and accurate diagnosis by the pathologists and physicians. The presentation can be acute, recurrent, or chronic. There are three paired major salivary glands in humans the parotid glands, the submandibular glands. Salivary gland disorders include inflammatory, bacterial, viral, and neoplastic etiologies.
Previously, researchers have shown the role of oral mucosa in covid19 infection xu, zhong, et al. However, you should know the locations and characteristics of the salivary glands. The presentation of salivary gland pathology to general practice is relatively infrequent. Salivary gland disorders american family physician. M aking a diagnosis of a salivary gland disorder can be difficult. Aside from the sublingual gland, the sublingual space is also comprised of the deep portion of the submandibular gland, the submandibular duct, the lingual arteryvein, and the lingual branch of the mandibular division of the trigeminal nerve cn v3. Presentation is key to diagnosing salivary gland disorders. Salivary gland dysfunction affects the flow, amount, or quality of saliva produced. Paramyxovirus is transmitted by droplet infections. It is difficult to determine whether the subjective alterations related to salivary flow hyposalivation, xerostomia, and dysgeusia can be attributed to hiv disease or haart 21. This syndrome has been called hivassociated salivary gland disease when it involves the salivary glands. Hyposalivation often results in a dry mouth condition called xerostomia, and this can cause tooth decay due to the loss of the protective properties of saliva.
1423 225 811 696 518 146 352 1298 1098 560 1069 50 128 1537 384 681 1255 1246 1014 1220 1316 989 504 737 1499 47 524 1280 1461 436 1100 1275 601 346 1335 832 972 639 762 559 835 419 233 524 373